​ First Representation The first reference of any kind to lip cosmetics exists on papyrus and referenced Egyptian women applying makeup. It's now known that Egyptians used focus-algin, iodine and bromine mannite to create lipstick — a combination that is actually lethal. Around the same time, Mesopotamian women crushed gemstones to decorate their lips. Queen's Rouge Queen Elizabeth's 16th century lipstick routine is well documented. Her Royal Highness used a mixture of cochin